The research projects listed below will define the best treatments to improve outcomes and quality of life.
Projects are based on priority questions identified by patients with early or advanced chronic kidney disease, their families and care providers.
Precision medicine in diabetic kidney disease
This project will take advantage of new techniques in molecular analysis to develop a personalized medicine approach to diagnosis and treatment of diabetic kidney disease.
Clinical trials of promising re-purposed drugs for ADPKD
Advances in ADPKD research have identified a number of promising therapeutic drugs. Several of these drugs are re-purposed compounds that are currently approved for diseases other than ADPKD. We plan to perform two pilot control trials of two of these therapeutic drugs to test the impact on ADPKD patients and to evaluate their potential.
ACHIEVE: Aldosterone inhibition and enhanced toxin removal in hemodialysis patients
Spironolactone is a drug that is very effective at reducing scarring of the heart and might help prevent heart-related deaths in patients with kidney failure. We will determine if spironolactone reduces heart related deaths and hospitalizations due to heart failure.
DISCO: Dialysis Symptom Control
Gabapentin and pramipexole are commonly used drugs for several conditions and are known to reduce restless legs in patients who do not have kidney disease. The results of DISCO will determine whether gabapentin, pramipexole, or both should be offered to patients receiving dialysis who suffer from restless legs.
Evaluation of sodium deposition in soft tissues of patients with kidney disease and its association with patient symptomatology
This study will try to examine sodium deposition in the skin, muscle and bones of patients with different kidney function and different dialysis modalities and its association with symptoms.
EMPATHY: Patient-reported outcomes clustered RCT
Evidence suggests that patient-reported outcomes measures (PROMs) have a positive impact in clinical practice; however, the impact on health outcomes and experiences is not fully understood. This research aims to fill this gap by evaluating the impact of routinely measuring and reporting patient-reported experience and outcomes, clinical outcomes, and healthcare utilization.
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